I will admit to having been on the Rivers train (EGDT) and many subsequent iterations related to protocolized sepsis therapy for over a decade.  This article by Josh Farkas does a good job of summarizing some different perspectives on the current state of evidence bases sepsis therapy.  What it doesn’t address is how protocolized sepsis therapy helps to create a shared mental model across disciplines which, I would argue may often be as important as individualized therapies with regard to patient outcomes.